Introduction
South America is a diverse and vibrant continent located in the Southern Hemisphere, mostly below the equator. It consists of 12 countries, including popular destinations like Brazil, Argentina, Peru, Chile, Colombia, and Bolivia.
- Introduction to South America Travel
South America is a continent of dramatic landscapes, vibrant cultures, and unforgettable experiences. With just two weeks to explore, it’s important to plan carefully to make the most of your time. This multi-country itinerary covers three countries—Peru, Bolivia, and Chile—offering a mix of historical sites, natural wonders, and local flavor. Whether you’re a first-time visitor or a seasoned traveler, this route will show you some of the continent’s most iconic highlights in a short but rewarding journey. - Day 1–3: Lima and Cusco, Peru – A Taste of Inca Culture
Begin your journey in Lima, Peru’s capital, known for its colonial architecture and thriving food scene. Spend a day exploring the historic center and sampling ceviche by the Pacific coast. Then, take a quick flight to Cusco, the former Inca capital nestled high in the Andes. Spend two days acclimating to the altitude while discovering ancient streets, lively markets, and nearby ruins like Sacsayhuamán. Cusco is the gateway to Machu Picchu and a cultural highlight of any South American adventure. - Day 4: Machu Picchu – The Crown Jewel of South America
From Cusco, take a scenic train ride or trek to the world-famous Machu Picchu. Hidden in the cloud forests of the Andes, this Incan citadel is a UNESCO World Heritage Site and one of the New Seven Wonders of the World. Spend a full day exploring the ruins, soaking in the mystical atmosphere, and learning about the site’s fascinating history. Return to Cusco in the evening for one last night in Peru before heading to Bolivia. - Day 5–6: La Paz, Bolivia – High Altitude Wonders
Fly from Cusco to La Paz, one of the highest cities in the world. The city’s geography is jaw-dropping, with houses climbing steep hillsides and the Andes as a backdrop. Ride the Mi Teleferico cable cars for sweeping views and visit sites like the Witches’ Market and Valle de la Luna (Moon Valley). Spend two days here adjusting to the even higher altitude, while enjoying Bolivia’s unique blend of traditional and modern culture. - Day 7–8: Uyuni Salt Flats – Nature’s Mirror
From La Paz, take a short flight or overnight bus to Uyuni, the gateway to the Salar de Uyuni, the largest salt flat in the world. This surreal landscape turns into a giant mirror during the rainy season, offering incredible photo opportunities. Explore this natural wonder on a 1- or 2-day jeep tour, which often includes stops at colorful lagoons, geysers, and cactus-covered islands. This is a must-see natural wonder that many travelers rank as a top highlight of their South America trip. - Day 9: Cross into Chile – San Pedro de Atacama
From Uyuni, cross the Bolivian border into northern Chile, arriving at the desert town of San Pedro de Atacama. Surrounded by salt flats, volcanoes, and alien-like landscapes, this charming town serves as the base for exploring the Atacama Desert, one of the driest places on Earth. Relax in town, visit the local artisan market, and get ready for more natural wonders on your next day. - Day 10: Explore the Atacama Desert – Mars on Earth
Spend the day visiting the Valle de la Luna (Moon Valley), the Altiplanic Lagoons, or the El Tatio Geysers. The Atacama Desert offers otherworldly scenery, stargazing opportunities, and a tranquil atmosphere that contrasts beautifully with the high-energy parts of the trip. With its unique geography and clear night skies, it’s an ideal stop to unwind before returning to city life. - Day 11–12: Santiago – Chile’s Cultural Capital
Take a flight from Calama (the nearest airport to Atacama) to Santiago, the capital of Chile. Nestled between the Andes and the Pacific, Santiago offers a sophisticated mix of old and new. Visit Plaza de Armas, the La Moneda Palace, and explore neighborhoods like Bellavista for street art, nightlife, and vibrant food. Spend a full day soaking in the city’s culture, or take a half-day wine tour in the nearby Maipo Valley. - Day 13–14: Valparaíso and Farewell
Wrap up your South American adventure with a short trip to the coastal city of Valparaiso, just two hours from Santiago. This UNESCO World Heritage Site is known for its colorful hillside homes, poetic charm (it was Pablo Neruda’s home), and street art-filled alleys. Enjoy a seafood lunch by the ocean and reflect on your journey before heading back to Santiago for your departure. With three countries under your belt and countless memories, this 2-week itinerary offers a truly enriching taste of South America. - Travel Tips and Final Thoughts
Traveling across South America in two weeks is ambitious but absolutely doable with careful planning. To save time, rely on local flights and night buses when possible. Make sure to account for altitude differences, pack layers for varying climates, and have a basic understanding of Spanish. While this itinerary covers a lot, it leaves room for spontaneity and local experiences that make the trip truly special. Whether it’s sipping coca tea in Cusco, gazing at endless salt flats, or watching the sunset in the Atacama Desert, South America is sure to leave a lasting impression.
Where to stay in South America
- Peru
Lima:
- Budget: Pariwana Hostel, Selina Miraflores
- Mid-range: Tierra Viva Miraflores, Casa Suyay
- Luxury: Belmond Miraflores Park, Country Club Lima Hotel
Cusco:
- Budget: Kokopelli Hostel, Milhouse Hostel
- Mid-range: El Mercado, Antigua Casona San Blas
- Luxury: JW Marriott El Convento, Belmond Hotel Monasterio
Machu Picchu (Aguas Calientes):
- Budget: Supertramp Hostel
- Mid-range: Casa del Sol Machu Picchu
- Luxury: Inkaterra Machu Picchu Pueblo Hotel
- Bolivia
La Paz:
- Budget: Wild Rover Hostel, Loki La Paz
- Mid-range: Hotel Rosario, La Casona Boutique Hotel
- Luxury: Atix Hotel, Casa Grande Hotel
Uyuni:
- Budget: Piedra Blanca Backpackers
- Mid-range: Hotel Jardines de Uyuni
- Luxury: Luna Salada Hotel (Salt Hotel), Palacio de Sal
- Chile
San Pedro de Atacama:
- Budget: Hostal Rural, Backpackers San Pedro
- Mid-range: Hotel Poblado Kimal
- Luxury: Tierra Atacama, Explora Atacama
Santiago:
- Budget: Rado Boutique Hostel, Happy House Hostel
- Mid-range: Hotel Cumbres Lastarria, Luciano K Hotel
- Luxury: The Ritz-Carlton Santiago, Singular Santiago
Valparaíso:
- Budget: Hostal Po
- Mid-range: Hotel Fauna
- Luxury: Casa Higueras Boutique Hotel
Things to do in South America
- Visit Machu Picchu, Peru
One of the New Seven Wonders of the World, Machu Picchu is an iconic Incan citadel high in the Andes. You can hike the Inca Trail or take a train from Cusco for a once-in-a-lifetime experience.
- Explore the Uyuni Salt Flats, Bolivia
The Salar de Uyuni is the world’s largest salt flat—a surreal landscape that turns into a giant mirror during the rainy season. Take a 4×4 tour to visit colorful lagoons, volcanoes, and salt hotels.
- Discover the Amazon Rainforest (Brazil, Peru, Ecuador)
Go on a jungle expedition in the Amazon Basin, home to an unmatched variety of plants, animals, and indigenous cultures. You can base yourself in Manaus (Brazil), Iquitos (Peru), or Tena (Ecuador).
Day trip from South America
From Cusco, Peru
Machu Picchu (Day trip by train)
- Take a morning train to Aguas Calientes and visit Machu Picchu in one day.
- It’s a long day (~14 hrs round-trip), but doable with an early start.
Sacred Valley (Pisac, Ollantaytambo, Moray)
- Visit Inca ruins, local markets, and dramatic Andean landscapes just 1–2 hours from Cusco.
From Buenos Aires, Argentina
Colonia del Sacramento, Uruguay (Ferry day trip)
- A 1-hour ferry ride takes you to this charming colonial town with cobblestone streets and a UNESCO World Heritage Site designation.
Tigre Delta River Cruise
- Just 1 hour from the city, enjoy boat tours through the lush delta and explore riverside markets.
